Masking of messenger RNA by Y-box proteins
Sommerville, J. and Ladomery, M. (1996) Masking of messenger RNA by Y-box proteins. The FASEB Journal, 10. pp. 435-443. ISSN 0892-6638 Available from: http://eprints.uwe.ac.uk/10916
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Publisher's URL: http://www.fasebj.org/cgi/content/abstract/10/4/43...
The Y-box proteins are defined by their ability to bind to Y-box promoter elements and to help regulate transcription of a wide variety of genes. However, Y-box proteins are also identified as abundant proteins in the cytoplasm of germ cells, where they are found bound to stored mRNA molecules. Binding of Y-box proteins to mRNA sequences, both in vitro and in vivo, has been shown to effect their translational repression ("masking"). Here we discuss the ability of Y box proteins to recognize different nucleic acid structures and to become involved in regulation of both transcription and translation.