Increasing positive and expiratory pressure at extubation reduces subglottic secretion aspiration in a bench-top model

Hodd, J., Doyle, A., Carter, J., Albarran, J. and Young, P. (2010) Increasing positive and expiratory pressure at extubation reduces subglottic secretion aspiration in a bench-top model. Nursing In Critical Care, 15 (5). pp. 257-261. ISSN 1362-1017

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Publisher's URL: http://dx.doi.org/10.1111/j.1478-5153.2010.00422.x

Abstract

Aim: To estimate the ability of simulated tracheal suction, adjusting the positive end expiratory pressure (PEEP) settings on the ventilator or compressing a self-inflating bag to minimize aspiration during cuff deflation and extubation in a bench-top model. Background: During intubation, colonized secretions accumulate in the subglottic space above the endotracheal tube (ETT) cuff. Consequently, during cuff deflation and extubation, there is a risk of aspiration of the secretions. This may result in pneumonitis or pneumonia. There are a number of techniques used during cuff deflation and extubation to prevent secretion aspiration. Method: A model trachea was intubated and the proximal end of the ETT was attached to a mechanical ventilator. Ten millilitres of water was placed above the inflated cuff and then nine test protocols were implemented in a random order to simulate tracheal suction, adjusting the PEEP settings on the ventilator or compressing a self-inflating bag. The volume of water ‘aspirated’ by the model was determined by weighing the apparatus pre- and post-extubation. Statistical analysis was performed using regression analysis and heteroscedastic t tests with a Bonferroni correction. Results: The level of PEEP was negatively correlated with the volume of fluid aspirated [co-efficient −0·24 (99% confidence interval −0·31 to −0·17), R2 = 0·75]. Significantly less fluid was aspirated when a PEEP of 35 cmH2O was applied when compared with competing techniques. Discussion and conclusions: This study suggests that applying PEEP during cuff deflation and extubation is protective against aspiration. We conclude that unless there is a contraindication, the application of PEEP should be considered when extubating patients.

Item Type:Article
Uncontrolled Keywords:aspiration, intubation, extubation, tracheal, PEEP, positive end expiratory pressure, ventilation, ventilator bundle, patient safety
Faculty/Department:Faculty of Health and Applied Sciences > Department of Nursing and Midwifery
ID Code:11436
Deposited By: Dr J. Albarran
Deposited On:13 Dec 2010 09:23
Last Modified:12 Aug 2013 08:03

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