Matthews, L., Lawrance, L., Gray, D. and Gray, S. and Royal Glamorgan Hospital
An audit of rubella IgG antibody status in antenatal women in the Cwm Taf (south) NHS trust over a five year period. (2005 – 2009).
Epidemiology and Infection, 319 (11).
Available from: http://eprints.uwe.ac.uk/13624
Publisher's URL: http://dx.doi.org/10.1017/S0950268810002748
Rubella, a vaccine preventable infection, has serious implications for the foetus if contracted during pregnancy. This study examines the antibody status of 11987 pregnant women 2005 - 2009.
Results show a non significant decrease in those with antibody levels of < 4.0 UI/ml from 29/2312 (1.3%) in 2005 to 21/2447 (0.9%) in 2009 (χ² for linear trend = 0.279; p=0.56 but a significant increase in those with levels <10 IU/ml from 88/2312 (3.8%) in 2005 to 124/2447 (5.1%) in 2009 (χ² for linear trend = 10.27; p=0.001). In women born before 1983 (pre-pubertal vaccination) the proportion of first pregnancies with titres <4IU was 1.1% (21/2002) compared with 3.4% (69/2022) in those born after 1983 (χ² 25.176 p<0.0001) and 2.2% (44/2002) for titres <10IU compared to 14.0% (282/2022) for those born after 1983 (χ² 171.43 p<0.0001).
The potential impact of the increase is difficult to determine, requiring further monitoring.
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