An audit of rubella IgG antibody status in antenatal women in a NHS Trust over 5 years (2005–2009)

Matthews, L. A., Lawrance, L., Gray, D. and Gray, S. (2010) An audit of rubella IgG antibody status in antenatal women in a NHS Trust over 5 years (2005–2009). Epidemiology and Infection, 139 (11). pp. 1720-1726. ISSN 0950-2688 Available from:

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Rubella, a vaccine-preventable infection. This study examined the antibody status of 11 987 pregnant women during 2005–2009. Results showed a non-significant decrease in those with antibody levels of <4.0 IU/ml from 29/2312 (1.3%) in 2005 to 21/2447 (0.9%) in 2009 (x2 for linear trend=0.279, P=0.56) but a significant increase in those with levels of <10 IU/ml from 88/2312 (3.8%) in 2005 to 124/2447 (5.1%) in 2009 (x2 for linear trend=10.27, P=0.001). In women born before 1983 (pre-pubertal vaccination) the proportion of first pregnancies with titres <4 IU was 1.1% (21/2002) compared to 3.4% (69/2022) in those born after 1983 (x2=25.176,P<0.0001) and 2.2% (44/2002) for titres <10 IU compared to 14.0% (282/2022) for those born after 1983 (x2=171.43, P<0.0001). The potential impact of the increase is difficult to determine, requiring further monitoring. This paper discusses the effect of changing immunization programmes on rubella susceptibility in pregnant women.

Item Type:Article
Uncontrolled Keywords:congenital (intrauterine) infection, immunization, MMR vaccination, rubella
Faculty/Department:Faculty of Health and Applied Sciences > Department of Health and Social Sciences
ID Code:13715
Deposited By: C. Foyle
Deposited On:31 Jan 2011 12:45
Last Modified:14 Apr 2017 19:50

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