Breath ammonia analysis: Clinical application and measurement

Hibbard, T. and Killard, A. (2011) Breath ammonia analysis: Clinical application and measurement. Critical Reviews in Analytical Chemistry, 41 (1). pp. 21-35. ISSN 1040-8347 Available from:

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This review covers in detail the complexity of human breath, how the body metabolises ammonia, clinical conditions which are directly related to regulation of ammonia concentration, and analysis of current techniques that are capable of detecting breath ammonia. Focusing on these areas provides the information needed to develop a breath ammonia sensor for monitoring dysfunction of the human body. Human breath has been broken down into its key components which are necessary for proper understanding of what to look for when attempting to isolate volatile organic compounds. A pathway has been shown which explains the origin of ammonia in the body and how it is processed within a healthy system. Following this, the hazards of several dysfunctions related to the broken ammonia pathway have been discussed. It is essential that technicians have knowledge of these inner workings of the human body along with current technology. Thus, the advantages and disadvantages of techniques from chemical ionisation, gas chromatography, laser spectroscopy, and chemical sensing have been discussed.

Item Type:Article
Uncontrolled Keywords:breath ammonia analysis, ammonia metabolism, clinical applications, analytical techniques
ID Code:14818
Deposited By: Professor T. Killard
Deposited On:07 Jun 2011 11:57
Last Modified:16 Nov 2016 23:30

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