Age-related differences in the effect of osmotic pressure on liver mitochondrial respiration in rats
Doran (nee Udovikova), O. and Lemeshko, V. V. and Kharkiv State University, Ukraine (1991) Age-related differences in the effect of osmotic pressure on liver mitochondrial respiration in rats. Biulleten Eksperimental'noi Biologii i Mediciny, 111 (2). pp. 150-152.
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Publisher's URL: http://www.ncbi.nlm.nih.gov/pubmed/1854956
The subject under investigation is the influence of osmotic pressure of incubation medium (25-500 mM of sucrose) upon the respiration and the respiration control (RC) of mitochondria of the liver of rats aged 1, 3, 12 and 24 months when oxidizing succinate. In a medium with 0.3 M of sucrose the respiration rate under condition 3 (V3) and RC increased from the age of 1 to 12 months and decreased by 24 months. In a medium with 0.15 M of sucrose the age differences have not been observed. In a uncoupling state the osmotic dependence of the respiration of mitochondria of 1- and 12-month-old rats did not vary. It is assumed that with age there is a change in the rate of structural coupling of the carrier of adenine nucleotides with H(+)-ATP synthetase complex and (or) the viscosity of the matrix.