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Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): Randomised controlled trial

Hay, Alastair D.; Costelloe, C�ire; Redmond, Niamh M.; Montgomery, Alan A.; Peters, Tim J.; Fletcher, Margaret; Hollinghurst, Sandra

Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): Randomised controlled trial Thumbnail


Authors

Alastair D. Hay

C�ire Costelloe

Niamh M. Redmond

Alan A. Montgomery

Tim J. Peters

Margaret Fletcher

Sandra Hollinghurst



Abstract

Objective: To investigate whether paracetamol (acetaminophen) plus ibuprofen are superior to either drug alone for increasing time without fever and the relief of fever associated discomfort in febrile children managed at home. Design: Individually randomised, blinded, three arm trial. Setting: Primary care and households in England. Participants: Children aged between 6 months and 6 years with axillary temperatures of at least 37.8°C and up to 41.0°C. Intervention: Advice on physical measures to reduce temperature and the provision of, and advice to give, paracetamol plus ibuprofen, paracetamol alone, or ibuprofen alone. Main outcome measures: Primary outcomes were the time without fever (

Citation

Peters, T. J., Montgomery, A. A., Redmond, N. M., Costelloe, C., Hay, A. D., Fletcher, M., & Hollinghurst, S. (2008). Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): Randomised controlled trial. BMJ, 337(7672), 729-733. https://doi.org/10.1136/bmj.a1302

Journal Article Type Article
Publication Date Sep 27, 2008
Deposit Date Jun 29, 2011
Publicly Available Date Dec 2, 2016
Journal BMJ
Print ISSN 0959-8138
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 337
Issue 7672
Pages 729-733
DOI https://doi.org/10.1136/bmj.a1302
Keywords paracetamol, ibuprofen, treatment, fever, children, (PITCH)
Public URL https://uwe-repository.worktribe.com/output/1018988
Publisher URL http://dx.doi.org/10.1136/bmj.a1302

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