Louise J. Pankhurst
Evaluation of inflammatory effects of airborne endotoxin emitted from composting sources
Pankhurst, Louise J.; Deacon, Lewis J.; Tyrrel, Sean F.; Hayes, Enda T; Drew, Gillian H; Liu, Jian; Longhurst, Philip; Abate, Wondwossen; Pollard, Simon; Longhurst, James; Jackson, Simon K.
Authors
Lewis J. Deacon
Sean F. Tyrrel
Enda Hayes Enda.Hayes@uwe.ac.uk
Prof in Air Quality & Carbon Management/School Director (Research & Enterprise)
Gillian H Drew
Jian Liu
Philip Longhurst
Wondwossen Abate
Simon Pollard
Assistant Vice Chancellor, Environment and Sustainability Jim Longhurst James.Longhurst@uwe.ac.uk
Professor
Simon K. Jackson
Abstract
Because of the lack of effective methodology, the biological effects of environmental endotoxin have not been assessed. Here we have collected and measured airborne endotoxin at different locations around composting sites. Increased endotoxin concentrations were observed close to composting activities and also at nearby boundary areas. Analysis of proinflammatory effects of the environmental endotoxin on interleukin (IL)-8 and IL-6 release from human D562 pharyngeal epithelial and MM6 monocytic cell cultures showed an association between endotoxin level and cytokine induction. The cytokine-inducing effect of bioaerosol extracts was inhibited by polymyxin B, indicating that endotoxin was the cause of cytokine responses we found. The environmental endotoxin was also more active for stimulating cytokines in airway epithelial cells than commercially purified Escherichia coli endotoxin. Our results suggest that these in vitro inflammatory cell models may contribute to the assessment of health impacts of environmental endotoxin. Environ. Toxicol. Chem. 2011; 30:602-606. © 2011 SETAC Copyright © 2011 SETAC.
Citation
Tyrrel, S. F., Deacon, L. J., Pankhurst, L. J., Liu, J., Abate, W., Hayes, E. T., …Jackson, S. K. (2011). Evaluation of inflammatory effects of airborne endotoxin emitted from composting sources. Environmental Toxicology and Chemistry, 30(3), 602-606. https://doi.org/10.1002/etc.434
Journal Article Type | Article |
---|---|
Publication Date | Mar 1, 2011 |
Journal | Environmental Toxicology and Chemistry |
Print ISSN | 0730-7268 |
Electronic ISSN | 1552-8618 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 30 |
Issue | 3 |
Pages | 602-606 |
DOI | https://doi.org/10.1002/etc.434 |
Keywords | endotoxin, composting, in vitro, cytokine |
Public URL | https://uwe-repository.worktribe.com/output/969878 |
Publisher URL | http://dx.doi.org/10.1002/etc.434 |
You might also like
A university’s transformational change agenda
(2023)
Book Chapter
Air and Water Pollution XXX
(2022)
Book
Challenges and opportunities for local action to improve air quality
(2022)
Presentation / Conference