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Predictors of immune response and reactogenicity to AS03B-adjuvanted split virion and non-adjuvanted whole virion H1N1 (2009) pandemic influenza vaccines

Andrews, Nick J.; Walker, Woolf T.; Finn, Adam; Heath, Paul T.; Collinson, Andrew C.; Pollard, Andrew J.; Snape, Matthew D.; Faust, Saul N.; Waight, Pauline A.; Hoschler, Katja; Sheasby, Liz; Waddington, Claire; Kerridge, Simon; Chalk, Jeremy; Reiner, Amanda; John, Tessa; Fletcher, Margaret; Allen, Ruth; Fineman, Natalie; Wilkins, Su; Casey, Michelle; Michaelis, Louise; Oeser, Clarissa; Okike, Ifeanyichukwu; Ladhani, Shamez; Miller, Elizabeth

Authors

Nick J. Andrews

Woolf T. Walker

Adam Finn

Paul T. Heath

Andrew C. Collinson

Andrew J. Pollard

Matthew D. Snape

Saul N. Faust

Pauline A. Waight

Katja Hoschler

Liz Sheasby

Claire Waddington

Simon Kerridge

Jeremy Chalk

Amanda Reiner

Tessa John

Margaret Fletcher

Ruth Allen

Natalie Fineman

Su Wilkins

Michelle Casey

Louise Michaelis

Clarissa Oeser

Ifeanyichukwu Okike

Shamez Ladhani

Elizabeth Miller



Abstract

In 2009, 943 children aged 6 months to 10 years were randomised to receive two doses of an oil-in water AS03B-adjuvanted split virion or a non-adjuvanted whole virion H1N1 (2009) vaccine. The large numbers allowed investigation of possible predictors of immune response and reactogenicity. We used regression analysis to examine the effect of variables including past receipt of seasonal vaccine, antipyretics post-vaccination, interval between doses and pre-existing antibodies to H1N1 (2009) on immunogenicity. We also examined the relationship between immunogenicity and reactogenicity and whether prior infection or underlying conditions affected reactogenicity. For both vaccines, haemagglutination-inhibition titres were 60% higher in children with fever ≥38. °C after vaccination and 29% lower in those previously given seasonal vaccine. Early use of antipyretics did not affect immunogenicity. Post-vaccination titres were higher with longer intervals between doses and in those with evidence of prior infection, but reactogenicity in the latter was unaffected. In the adjuvanted vaccine group, reactions were more common in children with atopy. Both vaccines were safe and immunogenic in those with prior infection. Reduction in the interval between doses for earlier protection would be at the cost of reduced immunogenicity. The effect of seasonal vaccine on immunogenicity merits further investigation. © 2011 Elsevier Ltd.

Citation

Andrews, N. J., Walker, W. T., Finn, A., Heath, P. T., Collinson, A. C., Pollard, A. J., …Miller, E. (2011). Predictors of immune response and reactogenicity to AS03B-adjuvanted split virion and non-adjuvanted whole virion H1N1 (2009) pandemic influenza vaccines. Vaccine, 29(45), 7913-7919. https://doi.org/10.1016/j.vaccine.2011.08.076

Journal Article Type Article
Publication Date Oct 19, 2011
Journal Vaccine
Print ISSN 0264-410X
Electronic ISSN 1873-2518
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 29
Issue 45
Pages 7913-7919
DOI https://doi.org/10.1016/j.vaccine.2011.08.076
Keywords predictors of immune response, reactogenicity, AS03B-adjuvanted split virion, non-adjuvanted whole virion H1N1, pandemic influenza vaccines
Public URL https://uwe-repository.worktribe.com/output/958590
Publisher URL http://dx.doi.org/10.1016/j.vaccine.2011.08.076


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