Pain intensity and quality of life perception in children with hypermobility syndrome

Fatoye, F., Palmer, S., Macmillan, F. and Rowe, P. (2012) Pain intensity and quality of life perception in children with hypermobility syndrome. Rheumatology International, 32 (5). pp. 1277-1284. ISSN 1437-160X Available from:

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Hypermobility syndrome (HMS) is a major source of morbidity in children. Impaired quality of life (QoL) has been observed recently in adults with HMS however, this issue is yet to be investigated in children with this condition. This study compared pain intensity and QoL in children with HMS with healthy controls. It also examined the relationship between pain intensity and QoL in children with HMS. Following ethical approval, 29 children diagnosed with HMS and 37 healthy children aged 8–15 years participated. Informed written consent was obtained from participants and their parents/guardians. Average knee pain over the past week was examined using the Coloured Analogue Scale. QoL was measured via the Pediatric Quality of Life Inventory. Mann–Whitney U tests were performed to compare pain and QoL scores between the two groups. Spearman Rho correlation analysis was performed to examine the relationship between pain and QoL. Overall QoL scores in each domain were significantly lower in children with HMS (all p<0.001) compared with the controls. Pain intensity was significantly higher in children with HMS compared with their healthy counterparts (p<0.001). A strong negative correlation was observed between pain intensity and overall QoL and all the domains (r range = -0.614 to -0.717; all p<0.001). In conclusion, the findings of the present study imply that pain and QoL assessment might form important components of clinical examination for children diagnosed with HMS. These children may benefit from appropriate treatment programmes to alleviate pain intensity and improve QoL.

Item Type:Article
Additional Information:Published online before print: 25th January, 2011
Uncontrolled Keywords:hypermobility syndrome, pain, quality of life, children, knee joint
Faculty/Department:Faculty of Health and Applied Sciences
ID Code:16591
Deposited By: Professor S. Palmer
Deposited On:03 Apr 2012 09:10
Last Modified:15 Nov 2016 23:16

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