The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro

Qualtrough, D. , Singh, K. , Banu, N. , Paraskeva, C. and Pignatelli, M. (2009) The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro. British Journal of Cancer (101). pp. 1124-1129. ISSN 0007-0920

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Publisher's URL: http://dx.doi.org/10.1038/sj.bjc.6605286

Abstract

BACKGROUND: Fascin is overexpressed in many cancers, including colorectal, but its role in the malignant transformation of benign colorectal adenomas is unclear. METHODS: Immunohistochemical analysis of fascin expression was carried out in resected human colorectal adenoma specimens. The effects of forced overexpression of fascin on adenoma cell motility were also analysed. RESULTS: We show fascin overexpression in adenomas increasing with tumour size, histological type, and degree of dysplasia and increased cell motility in adenoma cell lines following fascin transfection. CONCLUSION: These data suggest an important role for fascin in the malignant progression of colorectal tumours.

Item Type:	Article
Uncontrolled Keywords:	colon, adenoma, fascin, migration
Faculty/Department:	?? cen_crib_2010 ??
ID Code:	17300
Deposited By:	E. Heathcote
Deposited On:	20 Sep 2012 15:42
Last Modified:	22 Nov 2012 15:53