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Role of splice variants in the metastatic progression of prostate cancer

Hagen, Rachel M.; Ladomery, Michael

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Authors

Rachel M. Hagen



Abstract

AS (alternative splicing) and its role in disease, especially cancer, has come to forefront in research over the last few years. Alterations in the ratio of splice variants have been widely observed in cancer. Splice variants of cancer-associated genes have functions that can alter cellular phenotype, ultimately altering metastatic potential. As metastases are the cause of approximately 90% of all human cancer deaths, it is crucial to understand how AS is dysregulated in metastatic disease. We highlight some recent studies into the relationship between altered AS of key genes and the initiation of prostate cancer metastasis. ©The Authors Journal compilation ©2012 Biochemical Society.

Citation

Hagen, R. M., & Ladomery, M. (2012). Role of splice variants in the metastatic progression of prostate cancer. Biochemical Society Transactions, 40(4), 870-874. https://doi.org/10.1042/BST20120026

Journal Article Type Conference Paper
Publication Date Aug 1, 2012
Deposit Date Oct 19, 2012
Publicly Available Date Nov 15, 2016
Journal Biochemical Society Transactions
Print ISSN 0300-5127
Electronic ISSN 1470-8752
Publisher Portland Press
Peer Reviewed Peer Reviewed
Volume 40
Issue 4
Pages 870-874
DOI https://doi.org/10.1042/BST20120026
Keywords alternative splicing, central alternative exon, epidermal growth factor, metastasis, prolactin, prostate cancer
Public URL https://uwe-repository.worktribe.com/output/953280
Publisher URL http://dx.doi.org/10.1042/BST20120026
Additional Information Additional Information : This is a review article

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