Hagen, R. M. and Ladomery, M.
Role of splice variants in the metastatic progression of prostate cancer.
Biochemical Society Transactions, 40 (4).
Available from: http://eprints.uwe.ac.uk/17489
- Published Version
Publisher's URL: http://dx.doi.org/10.1042/BST20120026
AS (alternative splicing) and its role in disease, especially cancer, has come to forefront in research over
the last few years. Alterations in the ratio of splice variants have been widely observed in cancer. Splice
variants of cancer-associated genes have functions that can alter cellular phenotype, ultimately altering
metastatic potential. As metastases are the cause of approximately 90% of all human cancer deaths, it is
crucial to understand how AS is dysregulated in metastatic disease. We highlight some recent studies into
the relationship between altered AS of key genes and the initiation of prostate cancer metastasis.
|Additional Information:||This is a review article|
|Uncontrolled Keywords:||alternative splicing, central alternative exon, epidermal growth factor, metastasis, prolactin, prostate cancer|
Dr M. Ladomery
|Deposited On:||19 Oct 2012 11:48|
|Last Modified:||16 Aug 2013 22:22|
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