Adherence therapy for medication non-compliant patients with hypertension: A randomised controlled trial
Alhalaiqa, F., Deane , K. H. O., Nawafleh, A. H., Clark, A. and Gray, R. (2011) Adherence therapy for medication non-compliant patients with hypertension: A randomised controlled trial. Journal of Human Hypertension, 26. pp. 117-126. ISSN 0950-9240 Available from: http://eprints.uwe.ac.uk/17604
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Publisher's URL: http://dx.doi.org/10.1038/jhh.2010.133
The objective of this study is to establish the efficacy of adherence therapy (AT) compared with treatment as usual (TAU) in reducing blood pressure (BP) in non-compliant hypertensive patients. This study was designed as a parallel-group single-blind randomised controlled trial. The study was carried out at three general hospital outpatient clinics in Jordan. A total of 136 non-compliant hypertensive patients with a mean baseline BP of 164.5mmHg (s.d. 10.0) over 102.2mmHg (s.d. 7.0) participated in the study. 7 weekly 20-min sessions of AT in addition to TAU. The main outcome of this study is systolic blood pressure (SBP) at 11-weeks follow-up. In all, 68 patients received TAU and 68 AT. Intention-to-treat analysis included all participants randomised. AT lowered SBP by −23.11mmHg (95% CI: −25.85, −20.36) and diastolic BP (DBP) by −15.18mmHg (95% CI: −17.55, −12.80) at 11 weeks compared with TAU. Adherence (measured by pill counting) was also improved in the AT group by 37% at 11 weeks compared with TAU. No significant adverse events were reported. AT increases adherence to medication for hypertension which then leads to a clinically important reduction in BP.