The modelling of blood coagulation behaviour using quartz crystal microbalance

Efremov, V., Killard, A., Byrne, B. and Lakshmanan, R. S. (2013) The modelling of blood coagulation behaviour using quartz crystal microbalance. Journal of Biomechanics, 46 (3). pp. 437-442. ISSN 0021-9290

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Publisher's URL: http://dx.doi.org/10.1016/j.jbiomech.2012.10.001

Abstract

Blood is a clinically-important analytical matrix that is routinely selected for disease monitoring. Having a clear understanding of the mechanisms involved in blood coagulation is a key consideration in haemostasis, with modern clinical practices requiring rapid, miniaturised and informative diagnostic platforms to reliably study changes in viscoelasticity (VE). Oscillatory transducers such as the Quartz Crystal Microbalance (QCM) have considerable potential in this area, provided that they present simple, linear rheometric readings which can be adequately analysed and interpreted. Hence, integrating QCM data obtained in the laboratory with mathematical modelling of acoustic interactions between quartz crystal surfaces and coagulating blood is an important consideration for modelling thrombus formation. Here, we provide a comprehensive overview of experimental and theoretical applications currently being employed to monitor and model the VE properties of coagulating blood when applied to a QCM resonator, with key emphasis on data modelling and interpretation.

Item Type:Article
Uncontrolled Keywords:quartz crystal microbalance, blood, coagulation, viscosity, viscoelasticity
Faculty/Department:Faculty of Health and Applied Sciences > Department of Biological, Biomedical and Analytical Sciences
ID Code:17674
Deposited By: Professor T. Killard
Deposited On:08 Nov 2012 15:52
Last Modified:12 Aug 2013 08:08

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