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The chronoamperometric and voltammetric behaviour of glutathione at screen-printed carbon micro-band electrodes modified with cobalt phthalocyanine

Honeychurch, Kevin C.; Hart, John P.

The chronoamperometric and voltammetric behaviour of glutathione at screen-printed carbon micro-band electrodes modified with cobalt phthalocyanine Thumbnail


Authors



Abstract

Screen-printed carbon electrodes (SPCEs) incorporating the electrocatalyst cobalt phthalocyanine (CoPC) have been successfully used for the manufacture of microband electrodes for the determination of reduced glutathione (GSH). Initially investigations were performed to explore the cyclic voltammetric behaviour of these electrodes with potassium ferrocyanide. It was shown that steady state behaviour occurred which is indicative of radial diffusion at a microelectrode. Current densities of 2173 μAcm-2 were obtained compared to 464.4 μAcm-2 for conventional sized (3 mm x 3 mm) screen-printed electrodes were obtained. At scan rates between 5 and 20 mV/s no significant increase in current response was observed. The application of these microband CoPC–SPCEs, to the measurement of GSH by both chronoamperometry and cyclic voltammetry was investigated. The chronoamperometric response was found to be linear between 50 µM and 8.0 mM with a detection limit of 7.3 µM using an applied potential of +0.25 V (vs. Ag/AgCl).

Citation

Honeychurch, K. C., & Hart, J. P. (2012). The chronoamperometric and voltammetric behaviour of glutathione at screen-printed carbon micro-band electrodes modified with cobalt phthalocyanine. Advances in Analytical Chemistry, 2(5), 46-52. https://doi.org/10.5923/j.aac.20120205.01

Journal Article Type Article
Publication Date Nov 5, 2012
Deposit Date Nov 21, 2012
Publicly Available Date Nov 15, 2016
Journal Advances in Analytical Chemistry
Print ISSN 2163-1557
Publisher Hans Publishers
Peer Reviewed Peer Reviewed
Volume 2
Issue 5
Pages 46-52
DOI https://doi.org/10.5923/j.aac.20120205.01
Keywords glutathione, cobalt phthalocyanine screen-printed carbon electrodes, voltammetry, chronoamperometry, microband electrodes
Public URL https://uwe-repository.worktribe.com/output/942111
Publisher URL http://article.sapub.org/10.5923.j.aac.20120205.01.html