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The redox behaviour of diazepam (Valium®) using a disposable screen-printed sensor and its determination in drinks using a novel adsorptive stripping voltammetric assay

Crew, Adrian; Honeychurch, Kevin C.; Crew, Adrian P.; Northall, Hannah; Radbourne, Stuart; Davies, Owian; Newman, Sam; Hart, John P.

Authors

Adrian Crew

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Dr Adrian Crew Adrian.Crew@uwe.ac.uk
Senior Lecturer in Environmental Microbiology

Hannah Northall

Stuart Radbourne

Owian Davies

Sam Newman



Abstract

In this study we investigated the possibility of applying disposable electrochemical screen-printed carbon sensors for the rapid identification and quantitative determination of diazepam in beverages. This was achieved utilising a previously unreported oxidation peak. The origin of this peak was investigated further by cyclic voltammetry and gas chromatography/mass spectroscopy. At pH 6 the voltammetric behaviour of this oxidation process was found to involve adsorption of the drug allowing for the development of an adsorptive stripping voltammetric assay. Experimental conditions were then optimised for the determination of diazepam in a beverage sample using a medium exchange technique. It was shown that no elaborate extraction procedures were required as the calibration plots obtained in the absence and presence of the beverage were very similar. © 2013 Elsevier B.V.

Citation

Crew, A., Honeychurch, K. C., Crew, A. P., Northall, H., Radbourne, S., Davies, O., …Hart, J. P. (2013). The redox behaviour of diazepam (Valium®) using a disposable screen-printed sensor and its determination in drinks using a novel adsorptive stripping voltammetric assay. Talanta, 116, 300-307. https://doi.org/10.1016/j.talanta.2013.05.017

Journal Article Type Article
Publication Date Jan 1, 2013
Journal Talanta
Print ISSN 0039-9140
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 116
Pages 300-307
DOI https://doi.org/10.1016/j.talanta.2013.05.017
Keywords diazepam, beverages, cyclic voltammetry, drug screening, electrochemical sensor, screen-printed
Public URL https://uwe-repository.worktribe.com/output/931749
Publisher URL http://dx.doi.org/10.1016/j.talanta.2013.05.017