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A pilot study of faecal volatile organic compounds in faeces from cholera patients in Bangladesh to determine their utility in disease diagnosis

Probert, C. S.J.; Garner, Catherine E.; Ratcliffe, Norman M.; Smith, S.; Bardhan, P. K.

Authors

C. S.J. Probert

Catherine E. Garner

S. Smith

P. K. Bardhan



Abstract

The aim of this pilot study was to analyse the volatile organic compounds in faecal samples collected from cholera patients in Bangladesh to determine biomarkers that could be used for disease diagnosis. Samples were collected from patients at the International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh and also from healthy controls at the same institution. The volatile organic compounds were extracted from the headspace above the sample using solid phase microextraction and analysed using gas chromatography-mass spectrometry. A biomarker was identified in the cholera samples that could be used for disease diagnosis. Crown Copyright © 2009.

Citation

Probert, C. S., Garner, C. E., Smith, S., Bardhan, P. K., & Ratcliffe, N. M. (2009). A pilot study of faecal volatile organic compounds in faeces from cholera patients in Bangladesh to determine their utility in disease diagnosis. Transactions of The Royal Society of Tropical Medicine and Hygiene, 103(11), 1171-1173. https://doi.org/10.1016/j.trstmh.2009.02.004

Journal Article Type Article
Publication Date Nov 1, 2009
Deposit Date Jul 11, 2013
Journal Transactions of the Royal Society of Tropical Medicine and Hygiene
Print ISSN 0035-9203
Publisher Oxford University Press (OUP)
Peer Reviewed Peer Reviewed
Volume 103
Issue 11
Pages 1171-1173
DOI https://doi.org/10.1016/j.trstmh.2009.02.004
Keywords cholera, diarrhoea, volatile organic compounds, solid phase microextraction, gas chromatography mass spectrometry, Bangladesh
Public URL https://uwe-repository.worktribe.com/output/1002629
Publisher URL http://dx.doi.org/10.1016/j.trstmh.2009.02.004