A simple computational cell: Coupling boolean gene and protein networks

Bull, L. (2012) A simple computational cell: Coupling boolean gene and protein networks. Artificial Life, 18 (2). pp. 223-236. ISSN 1064-5462 Available from: http://eprints.uwe.ac.uk/20732

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Publisher's URL: http://mitpress.mit.edu


This article presents an abstract, tunable model containing two of the principal information-processing features of cells and explores its use with simulated evolution. The random Boolean model of genetic regulatory networks is extended to include a protein interaction network. The underlying behavior of the resulting two coupled dynamical networks is investigated before their evolvability is explored using a version of the NK model of fitness landscapes.

Item Type:Article
Uncontrolled Keywords:protein interaction networks, automata, biology, model, regulatory networks
Faculty/Department:Faculty of Environment and Technology > Department of Computer Science and Creative Technologies
ID Code:20732
Deposited By: M. Clarke
Deposited On:15 Jul 2013 09:26
Last Modified:15 Nov 2016 22:20

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