Evolving Boolean regulatory networks with epigenetic control

Bull, L. (2014) Evolving Boolean regulatory networks with epigenetic control. Biosystems, 116. pp. 36-42. ISSN 0303-2647 Available from: http://eprints.uwe.ac.uk/25783

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Publisher's URL: http://dx.doi.org/10.1016/j.biosystems.2013.12.004


The significant role of epigenetic mechanisms within natural systems has become increasingly clear. This paper uses a recently presented abstract, tunable Boolean genetic regulatory network model to explore aspects of epigenetics. It is shown how dynamically controlling transcription via a DNA methylation-inspired mechanism can be selected for by simulated evolution under various single and multicellular scenarios. Further, it is shown that the effects of such control can be inherited without detriment to fitness.

Item Type:Article
Additional Information:© 2014, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords:evolution, Boolean
Faculty/Department:Faculty of Environment and Technology > Department of Computer Science and Creative Technologies
ID Code:25783
Deposited By: Professor L. Bull
Deposited On:17 Jun 2015 10:06
Last Modified:15 Nov 2016 19:58

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