Chromosome translocations and covert leukemic clones are generated during normal fetal development.
PNAS, 99 (12).
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Publisher's URL: http://dx.doi.org/10.1073/pnas.112218799
|Additional Information:||This paper provided molecular biologic evidence indicating that most cases of acute leukaemia in infants are initiated by chromosomal and genetic alterations prenatally, although leukaemia initiation by chromosomal changes was far more common than the rarity of the disease would suggest and giving rise to the multi-hit theory.|
|Uncontrolled Keywords:||chromosome translocations, covert leukemic clones, normal fetal development|
|Faculty/Department:||Faculty of Environment and Technology|
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|Deposited On:||22 Jan 2010 15:10|
|Last Modified:||12 Aug 2013 07:58|
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