Salmonid melanin-concentrating hormone inhibits corticotrophin release
Baker, B. I., Bird, D. J. and Buckingham, J. C. (1985) Salmonid melanin-concentrating hormone inhibits corticotrophin release. Journal of Endocrinology, 106 (2). R5-R8. ISSN 0022-0795
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Publisher's URL: http://dx.doi.org/10.1677/joe.0.106R005
Melanin-concentrating hormone (MCH) is a neural peptide associated with colour change in fishes. We show here that it also inhibits corticotrophin (ACTH) secretion. Synthetic salmonid MCH at a concentration of 100 pmol/l reduced the in-vitro release of ACTH by pars distales (pDs) taken from stressed trout. At lower concentrations (10 pmol/l) the peptide inhibited CRF-41-induced secretion of ACTH by pDs removed from unstressed trout, while at higher concentrations (10 nmol/l) it reduced the corticotrophic response of rat pituitary tissue to CRF-41.