Immunocytochemical demonstration of melanin-concentrating hormone and proopiomelanocortin-like products in the brain of the trout and carp
Bird, D. J. print, Baker, B. I. print and Kawauchi, H. print (1989) Immunocytochemical demonstration of melanin-concentrating hormone and proopiomelanocortin-like products in the brain of the trout and carp. General and Comparative Endocrinology, 74 (3). pp. 442-450. ISSN 0016-6480
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Publisher's URL: http://dx.doi.org/10.1016/S0016-6480%2889%2980042-...
Immunocytochemistry on frozen sections revealed that in both the trout and the carp, parvocellular neurones located in the medial basal hypothalamus (medial nucleus lateralis tuberis) were immunostained by antisera against three molecules known to be derived from the proopiomelanocortin (POMC) molecule, viz: α-melanocyte-stimulating hormone (αMSH), ACTH, and salmonid NPP—the whole N-terminal sequence preceding ACTH in the POMC precursor. Axons from these neurones extended into various regions of the brain but did not appear to project into the pituitary gland. Antiserum against salmonid melaninconcentrating hormone (MCH) immunostained magnocellular neurones in the lateral basal hypothalamus (lateral nucleus lateralis tuberis). Axons from some of these neurones projected into the brain while other axons extended into the pituitary gland. In the carp, but not in the trout, some MCH neurones were also immunostained by antisera against αMSH but not by antisera against the other POMC molecules.
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