Current considerations for the effective safety evaluation of drugs in vitro
Xu, J. and Jackson, S. K. (2009) Current considerations for the effective safety evaluation of drugs in vitro. Mini Reviews in Medicinal Chemistry, 9 (7). pp. 861-868. ISSN 1389-5575 Available from: http://eprints.uwe.ac.uk/7125
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Publisher's URL: http://dx.doi.org/10.2174/138955709788452577
As the traditional in vivo tests are gradually shifting into in vitro tests, some new issues become apparent. This review discusses the essential considerations in endpoint selection, cell model quality, exposure concentration and linking factors between in vitro and in vivo studies in using in vitro models in risk assessment.