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Lysophospholipid acyltransferases: Novel potential regulators of the inflammatory response and target for new drug discovery

Jackson, Simon K.; Abate, Wondwossen; Tonks, Amanda J.

Authors

Simon K. Jackson

Wondwossen Abate

Amanda J. Tonks



Abstract

Molecular and biochemical analyses of membrane phospholipids have revealed that, in addition to their physico-chemical properties, the metabolites of phospholipids play a crucial role in the recognition, signalling and responses of cells to a variety of stimuli. Such responses are mediated in large part by the removal and/or addition of different acyl chains to provide different phospholipid molecular species. The reacylation reactions, catalysed by specific acyltransferases control phospholipid composition and the availability of the important mediators free arachidonic acid and lysophospholipids. Lysophospholipid acyltransferases are therefore key control points for cellular responses to a variety of stimuli including inflammation. Regulation or manipulation of lysophospholipid acyltransferases may thus provide important mechanisms for novel anti-inflammatory therapies. This review will highlight mammalian lysophospholipid acyltransferases with particular reference to the potential role of lysophosphatidylcholine acyltransferase and its substrates in sepsis and other inflammatory conditions and as a potential target for novel anti-inflammatory therapies. © 2008 Elsevier Inc. All rights reserved.

Citation

Jackson, S. K., Abate, W., & Tonks, A. J. (2008). Lysophospholipid acyltransferases: Novel potential regulators of the inflammatory response and target for new drug discovery. Pharmacology and Therapeutics, 119(1), 104-114. https://doi.org/10.1016/j.pharmthera.2008.04.001

Journal Article Type Review
Publication Date Jul 1, 2008
Journal Pharmacology and Therapeutics
Print ISSN 0163-7258
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 119
Issue 1
Pages 104-114
DOI https://doi.org/10.1016/j.pharmthera.2008.04.001
Keywords lysophospholipid, acyltransferase, lipopolysaccharide, inflammation, sepsis, monocyte
Public URL https://uwe-repository.worktribe.com/output/1011235
Publisher URL http://dx.doi.org/10.1016/j.pharmthera.2008.04.001




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