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Rosiglitazone produces a greater reduction in circulating platelet activity compared with gliclazide in patients with type 2 diabetes mellitus-An effect probably mediated by direct platelet PPARγ activation

Morris, R H K; Khanolkar, M. P.; Thomas, A. W.; Green, J; Bolusani, H.; Jackson, Simon K.; Roberts, A. W.; Evans, L. M.

Authors

R H K Morris

M. P. Khanolkar

A. W. Thomas

J Green

H. Bolusani

Simon K. Jackson

A. W. Roberts

L. M. Evans



Abstract

Aims: Type 2 diabetes mellitus (T2DM) is associated with enhanced platelet activation. We conducted a randomised double-blind study to compare the effects of combination metformin and rosiglitazone or metformin and gliclazide therapy on platelet function in persons with T2DM. Methods: Fifty subjects on metformin monotherapy received either rosiglitazone 4 mg or gliclazide 80 mg. HbA1c, HOMA-R, markers of platelet activation, inflammation, endothelial activation and oxidative stress were measured at baseline and after 24 weeks of treatment. Separate in vitro platelet function studies were conducted on platelets pre-incubated with rosiglitazone and gliclazide. Results: A significantly greater reduction in platelet aggregation was observed in the rosiglitazone treated group compared to gliclazide. HbA1c and markers of endothelial activation were reduced to a similar extent in both groups. A significant reduction in HOMA-R, markers of inflammation and oxidative stress was only observed with rosiglitazone. Reduction in platelet aggregation with rosiglitazone correlated with reduction in oxidative stress. In the in vitro study, rosiglitazone produced significantly greater reduction in platelet aggregation compared with gliclazide. Conclusion: Greater reduction in platelet activity observed with rosiglitazone may be related to reduced oxidative stress and a possible direct PPARγ mediated effect on platelet function. © 2007 Elsevier Ireland Ltd. All rights reserved.

Citation

Khanolkar, M. P., Morris, R. H. K., Thomas, A. W., Bolusani, H., Roberts, A. W., Green, J., …Evans, L. M. (2008). Rosiglitazone produces a greater reduction in circulating platelet activity compared with gliclazide in patients with type 2 diabetes mellitus-An effect probably mediated by direct platelet PPARγ activation. Atherosclerosis, 197(2), 718-724. https://doi.org/10.1016/j.atherosclerosis.2007.07.020

Journal Article Type Article
Publication Date Apr 1, 2008
Journal Atherosclerosis
Print ISSN 0021-9150
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 197
Issue 2
Pages 718-724
DOI https://doi.org/10.1016/j.atherosclerosis.2007.07.020
Keywords type 2 diabetes mellitus, rosiglitazone, platelets
Public URL https://uwe-repository.worktribe.com/output/1013907
Publisher URL http://dx.doi.org/10.1016/j.atherosclerosis.2007.07.020


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