The post-transcriptional roles of WT1, a multifunctional zinc-finger protein

Morrison, A. A., Viney, R. L. and Ladomery, M. (2008) The post-transcriptional roles of WT1, a multifunctional zinc-finger protein. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1785 (1). pp. 55-62. ISSN 0304-419X

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Publisher's URL: http://dx.doi.org/10.1016/j.bbcan.2007.10.002

Abstract

WT1 was first described in 1990 as a tumour suppressor gene associated with Wilms tumour (nephroblastoma). It encodes a typical transcription factor with four C2–H2 zinc fingers in the C-terminus. However WT1 is surprisingly complex at multiple levels: it is involved in the development of several organ systems; and is both a tumour suppressor and oncogene. Here we review evidence that has accumulated over the past decade to suggest that as well as binding DNA, WT1 also binds mRNA targets via its zinc fingers and interacts with several splice factors. WT1's first reported post-transcriptional function is also reviewed. WT1's complex roles in development and disease now need to be understood in terms of both DNA and mRNA targets.

Item Type:Article
Uncontrolled Keywords:WT1, zinc-finger protein, mRNA binding protein, mRNP particle, splice factor, alternative splicing
Faculty/Department:Faculty of Health and Applied Sciences > Department of Biological, Biomedical and Analytical Sciences
ID Code:7139
Deposited By: H. Hammond
Deposited On:16 Jul 2010 07:54
Last Modified:12 Aug 2013 07:59

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