Avril A. Morrison
The post-transcriptional roles of WT1, a multifunctional zinc-finger protein
Morrison, Avril A.; Viney, Rebecca L.; Ladomery, Michael
Abstract
WT1 was first described in 1990 as a tumour suppressor gene associated with Wilms tumour (nephroblastoma). It encodes a typical transcription factor with four C2-H2 zinc fingers in the C-terminus. However WT1 is surprisingly complex at multiple levels: it is involved in the development of several organ systems; and is both a tumour suppressor and oncogene. Here we review evidence that has accumulated over the past decade to suggest that as well as binding DNA, WT1 also binds mRNA targets via its zinc fingers and interacts with several splice factors. WT1's first reported post-transcriptional function is also reviewed. WT1's complex roles in development and disease now need to be understood in terms of both DNA and mRNA targets. © 2007 Elsevier B.V. All rights reserved.
Citation
Morrison, A. A., Viney, R. L., & Ladomery, M. (2008). The post-transcriptional roles of WT1, a multifunctional zinc-finger protein. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1785(1), 55-62. https://doi.org/10.1016/j.bbcan.2007.10.002
Journal Article Type | Review |
---|---|
Publication Date | Jan 1, 2008 |
Journal | Biochimica et Biophysica Acta - Reviews on Cancer |
Print ISSN | 0304-419X |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 1785 |
Issue | 1 |
Pages | 55-62 |
DOI | https://doi.org/10.1016/j.bbcan.2007.10.002 |
Keywords | WT1, zinc-finger protein, mRNA binding protein, mRNP particle, splice factor, alternative splicing |
Public URL | https://uwe-repository.worktribe.com/output/1016087 |
Publisher URL | http://dx.doi.org/10.1016/j.bbcan.2007.10.002 |
You might also like
Going circular: history, present, and future of circRNAs in cancer.
(2023)
Journal Article
Epigenenetic regulation of alternative splicing: How lncRNAs tailor the message
(2021)
Journal Article