Nociceptin-induced modulation of human T cell function
Easten, K. H., Harry, R. A., Purcell, W. M. and McLeod, J. D. (2009) Nociceptin-induced modulation of human T cell function. Peptides, 30 (5). pp. 926-934. ISSN 0196-9781 Available from: http://eprints.uwe.ac.uk/7161
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Publisher's URL: http://dx.doi.org/10.1016/j.peptides.2009.01.021
There is an accumulating evidence for the immunoregulatory role of the neuropeptide, nociceptin/orphanin FQ (N/OFQ) however its role on T cell function requires elucidation. This study has demonstrated an inhibitory role for N/OFQ on SEB-activated T cell function. N/OFQ decreases T cell proliferation, which is abrogated when the costimulatory receptors CD80 and CD86 are blocked. In addition, evidence suggests that the immunoregulatory cytokines TGF-β, IFN-γ and nitric oxide (NO) are involved in the N/OFQ effect. N/OFQ also, through involvement of IFN and NO, induces the expression of the immunosuppressive modulator indoleamine 2,3-dioxygenase (IDO), suggesting a central role for IDO in the N/OFQ effect on T cell proliferation. The data presented in this report indicate a multi-faceted mechanism of action used by N/OFQ to modulate T cell function.