Evaluation of paramagnetic particles for use in a resonant coil magnetometer based magneto-immunoassay

Eveness, J., Kiely, J., Hawkins, P., Wraith, P. and Luxton, R. W. (2009) Evaluation of paramagnetic particles for use in a resonant coil magnetometer based magneto-immunoassay. Sensors & Actuators: B. Chemical, 139 (2). pp. 538-542. ISSN 0925-4005

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Publisher's URL: http://dx.doi.org/10.1016/j.snb.2009.03.078

Abstract

This paper describes work that formed a part of an investigation to increase the detection sensitivity of a magneto-immunoassay. The study involved the characterisation of paramagnetic particles (PMPs) from a range of manufacturers in order to determine parameters that influence the assay sensitivity. Magnetisation curves were produced for each PMP type using a vibrating sample magnetometer. A resonant coil magnetometer which incorporated of a planar, spiral coil integrated with a phase locked loop based detector was used to investigate the effect of PMP number and mass on the resonant frequency of the coil. In order to compare performance in an assay using a resonant coil magnetometer, the sensitivity for a monolayer of particles was evaluated. The results enabled the identification of parameters that were critical to achieving maximum sensitivity and, of the particles studied, the 0.75m diameter PMPs demonstrated the greatest sensitivity in the resonant coil magnetometer.

Item Type:Article
Uncontrolled Keywords:magneto-immunoassay; paramagnetic particles; resonant coil magnetometer.
Faculty/Department:Faculty of Health and Applied Sciences > Department of Biological, Biomedical and Analytical Sciences
Faculty of Environment and Technology > Department of Engineering Design and Mathematics
ID Code:80
Deposited By: Dr J. Kiely
Deposited On:24 Feb 2010 10:21
Last Modified:22 May 2014 15:50

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