The role of redox mechanisms in cell signalling

Hancock, J. T. (2009) The role of redox mechanisms in cell signalling. Molecular Biotechnology, 43 (2). pp. 162-166. ISSN 1073-6085

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Publisher's URL: http://dx.doi.org/10.1007/s12033-009-9189-1

Abstract

Functioning and efficient cell signalling is vital for the survival of cells. Over the years various components have been identified and recognised as crucial for the transduction of signals in cells. Many of the mechanisms allow for a relatively rapid switching of signals, on or off, with common examples being the G proteins and protein phosphorylation. However, recently it has become apparent that other modifications of amino acids are also important, and this includes reactions with nitric oxide, for example S-nitrosylation, and of particular relevance here, oxidation of cysteine residues. Such oxidation will be dependent on the redox status of the intracellular environment in which that protein resides, and this will in turn be dictated by the presence of pro-oxidants and antioxidants. Here, the chemistry of redox modification of amino acids is introduced, and a general overview of the role of redox in mediating signal transduction is given.

Item Type:Article
Uncontrolled Keywords:cysteine modification, hydrogen peroxide, nitric oxide, redox, S-nitrosylation, signal transduction, thiol
Faculty/Department:Faculty of Health and Applied Sciences > Department of Biological, Biomedical and Analytical Sciences
ID Code:8277
Deposited By: Dr J. Hancock
Deposited On:09 Jul 2010 09:13
Last Modified:12 Aug 2013 08:00

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