Cytochrome c, glutathione and the possible role of redox potentials in apoptosis
Hancock, J. T., Desikan, R. and Neill, S. (2003) Cytochrome c, glutathione and the possible role of redox potentials in apoptosis. Annals of the New York Academy of Sciences, 1010 (Apopto). pp. 446-448. ISSN 0077-8923
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Publisher's URL: http://dx.doi.org/10.1196/annals.1299.081
The redox environment of the cell is now thought to be extremely important to control the activity of many proteins. During apoptosis, the intracellular redox potential (Eh) becomes more positive, with possible consequences for the mechanisms of apoptosis. Glutathione and cytochrome c might both influence and be influenced by the cellular redox environment and therefore be important in the progression of apoptosis.