Antimicrobial properties of milk: Dependence on the presence of xanthine oxidase and nitrite
Hancock, J. T., Salisbury, V., Ovejero-Boglione, M. C., Cherry, R., Hoare, C., Eisenthal, R. and Harrison, R. (2002) Antimicrobial properties of milk: Dependence on the presence of xanthine oxidase and nitrite. Antimicrobial Agents and Chemotherapy, 46 (10). pp. 3308-3310. ISSN 0066-4804 Available from: http://eprints.uwe.ac.uk/8324
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Publisher's URL: http://dx.doi.org/10.1128/AAC.46.10.3308-3310.2002
Human and bovine milk inhibited the metabolic activity of Escherichia coli, as shown by luminescence monitoring of constructs expressing the luxCDABE genes. Inhibition was dependent on both xanthine oxidase (XO) activity and on the presence of nitrite, implying that XO-generated nitric oxide functions as an antibacterial agent.