Antimicrobial properties of milk: Dependence on the presence of xanthine oxidase and nitrite

Hancock, J. T. , Salisbury, V. , Ovejero-Boglione, M. C. , Cherry, R. , Hoare, C. , Eisenthal, R. and Harrison, R. (2002) Antimicrobial properties of milk: Dependence on the presence of xanthine oxidase and nitrite. Antimicrobial Agents and Chemotherapy, 46 (10). pp. 3308-3310. ISSN 0066-4804

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Publisher's URL: http://dx.doi.org/10.1128/AAC.46.10.3308-3310.2002

Abstract

Human and bovine milk inhibited the metabolic activity of Escherichia coli, as shown by luminescence monitoring of constructs expressing the luxCDABE genes. Inhibition was dependent on both xanthine oxidase (XO) activity and on the presence of nitrite, implying that XO-generated nitric oxide functions as an antibacterial agent.

Item Type:Article
Faculty/Department:Faculty of Health and Life Sciences > Department of Applied Sciences
~Pre-2012 Faculty Structure > Faculty of Health and Life Sciences > Department of Applied Sciences
~Pre-2010 Faculty Structure > Health and Life Sciences > School of Life Sciences > Centre for Research in Biomedicine
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ID Code:8324
Deposited By: Dr J. Hancock
Deposited On:09 Jul 2010 13:52
Last Modified:22 Nov 2012 15:38

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